1/12/2024 0 Comments Very low ldl cholesterol range![]() 10, 12, 20, 21The strong association between increased small, dense LDL particles and elevated triglycerides, for example, appears to be linked to the altered insulin sensitivity common in the metabolic syndrome and type 2 diabetes. 10, 18, 19Thus, levels of LDL may appear deceptively “normal” in cholesterol measurements.īeyond the importance of even modest elevations in LDL cholesterol in people with diabetes, it also appears that LDL cholesterol interacts with risk factors of the metabolic syndrome to magnify the risk of CVD. These particles contain less cholesterol than normal-sized LDL particles, but they are exceptionally atherogenic. 17 A large number of small, dense particles characterize the LDL fraction in diabetic individuals. In fact, LDL cholesterol levels may understimate cardiovascular risk in diabetes. ![]() Nonetheless, LDL cholesterol does not play less of a role in cardiovascular risk in people with type 2 diabetes. 12 Moreover,high LDL cholesterol levels (≥ 160 mg/dl) do not occur at higher-than-average rates in people with diabetes. 12 In fact,the most common LDL cholesterol level in diabetes is “borderline high” (130-159 mg/dl). In general, LDL cholesterol levels in people with diabetes are not higher than those in people without diabetes who are matched for age, sex, and body weight. Patients with diabetes frequently have lipid profiles that appear more benign than those of other high-risk people without diabetes. 1.1% P < 0.001) and with ST-segment elevation MI (8.5 vs. 7 In a recent analysis of pooled data from 11 trials of 62,036 patients with acute coronary syndromes conducted by the Thrombolysis in Myocardial Infarction Study Group, mortality at 30 days was significantly higher among diabetic than nondiabetic patients presenting with unstable angina/non-ST-segment elevation MI (2.1 vs. In the FINMONICA myocardial infarction (MI) register study, 28-day mortality after hospitalization for a first MI was nearly twofold higher in men with diabetes and almost threefold higher in women with diabetes compared with their nondiabetic counterparts. 1 The risk of death is particularly high in the early period after a CHD event. 5, 6Heart disease mortality, however, is two to four times higher in patients with diabetes compared with those without diabetes. ![]() 4 More recent studies have determined that diabetes is a coronary heart disease (CHD) risk equivalent based on findings that risk for coronary events in diabetic patients without previous CHD is equivalent to that of nondiabetic people with a history of CHD. ![]() 2, 3Nearly 30 years ago, the Framingham Heart Study established that individuals with diabetes have a two to three times higher risk of cardiovascular events than nondiabetic people. 1 Owing in part to the growing epidemic of obesity in the United States, the prevalence of diabetes is expected to more than double to 48 million people by 2050. adults-roughly 10% of the adult population-have diabetes. Current estimates indicate that 21 million U.S. ![]()
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